Allergic Reaction to Vaccines in Dogs

Overview of Canine Vaccine Reactions

Immunizations (or vaccines) are intended to stimulate the immune system so as to protect the dog from the infectious agent. However, this stimulation may cause some minor symptoms. Your dog may react to immunizations in ways that range from soreness at the site of injection to mild fever to allergic reactions, which can range from mild to severe.

Types of Vaccine Reactions in Dogs

• Mild. Mild reactions include fever, sluggishness, and loss of appetite. Mild reactions usually resolve without treatment.
• Moderate. Urticaria is a moderate vascular reaction of the skin marked by hives or wheals and rapid swelling and redness of the lips, around the eyes, and in the neck region. It is usually extremely itchy. Urticaria may progress to anaphylaxis, which is considered life-threatening. Urticaria is the most common reaction in dogs.
• Severe. The most severe reaction is anaphylaxis, a sudden, severe allergic response that produces breathing difficulties, collapse and possible death. Symptoms usually include sudden onset of vomiting, diarrhea, staggering, rapid drop in blood pressure, swelling of the larynx leading to airway obstruction (and inability to breathe), seizures and cardiovascular collapse or death. This reaction is life-threatening for your dog.

Both anaphylaxis and urticaria are reactions that are triggered by antibodies that the immune system has made to some portion of the vaccine and usually requires at least one previous exposure to the vaccine. The antibodies cause inflammatory cells like basophils and mast cells to release substances that cause the allergic reaction. The impact on the dog may be life threatening but if treated successfully the prognosis for long-term health is good. Mild reactions usually resolve without treatment.

Diagnosis of Allergic Reactions to Vaccines in Dogs

There is no diagnostic test for anaphylaxis or urticaria, but a quick physical exam will show common signs of an allergic reaction and the history will reveal recent vaccination.

Treatment of Allergic Reaction to Vaccines in Dogs

• Anaphylaxis is an extreme emergency. Your veterinarian will begin immediate emergency life support including establishing an open airway, oxygen administration, intravenous fluids to increase blood pressure and drugs such as epinephrine, diphenhydramine and corticosteroids. Dogs that survive the first few minutes usually return to normal health. Anaphylaxis usually occurs soon after vaccination, often while the dog is still in the veterinary clinic.
• Urticaria occurs soon after vaccination, often shortly after the animal gets home. Your veterinarian will recommend immediate return to the hospital for treatment. An oral antihistamine such as diphenhydramine (Benadryl®) may be recommended to initiate treatment. Urticaria is usually treated successfully with injectable corticosteroids like dexamethasone or prednisone. Antihistamines do little to help with acute allergic reactions but may be given by injection to help prevent recurrence of symptoms after steroids wear off.
• Mild vaccination reactions usually require no treatment. However, if the symptoms persist for more than 24 hours, call your veterinarian.

Home Care

Be sure to schedule vaccination appointments when you will be available to monitor your dog after the vaccine is administered. Be sure to call your veterinarian with any questions or concerns.

Preventative Care

The good news is that severe vaccination reactions are rare. The risk of anaphylaxis and urticaria are much more rare than the benefit of the vaccine in most cases. You can limit vaccines to those that prevent diseases to which your dog may be exposed. Your veterinarian is the best judge of what vaccines are needed to protect against the diseases in your area.

Your veterinarian will record any adverse reactions to vaccines to help prevent those vaccines from being administered again. It is a good idea to also keep a record yourself. Reactions are more commonly associated with vaccines for leptospira, rabies and parvovirus.