Piroxicam (Feldene®) for Dogs and Cats

Overview of Piroxicam for Dogs and Cats

Piroxicam, known as Feldene®, has been used in combination with other drugs to treat transitional cell carcinoma, a bladder cancer, in dogs and cats. Piroxicam is uncommonly used for pain and inflammation in dogs due to the availability and safety of other medications.
Piroxicam belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs).
These drugs relieve inflammation and pain by inhibiting synthesis of chemicals called prostaglandins.
Piroxicam also demonstrates effectiveness against fevers.
Piroxicam is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug.

Piroxicam has been used in combination with other drugs to treat transitional cell carcinoma, a bladder cancer, in dogs.
It can be used as an antiinflammatory and pain medication in cats.
Piroxicam has been used to treat chronic rhinitis in dogs and cats.

While generally safe and effective when prescribed by a veterinarian, piroxicam can cause side effects in some animals.
Piroxicam should not be used in animals with known hypersensitivity or allergy to the drug.
Piroxicam should be avoided in animals with a history of bleeding, inflammation or perforation of the stomach or intestinal mucosa (lining). It should also be avoided in animals with high blood pressure.
This drug must be used with caution in patients with heart failure.
Piroxicam may interact with other medications. Consult with your veterinarian to determine if other drugs your pet is receiving could interact with Piroxicam. Such drugs include diuretics or ACE-inhibitors (enalapril, benazepril, quinapril).
Side effects of piroxicam include stomach and intestinal ulcers and bleeding, dark or tarry stools (from bleeding into the intestines), vomiting, loss of appetite and peritonitis (from intestinal perforation). Some of these are life-threatening problems and they can occur relatively suddenly.
The potential for ulcers increases when piroxicam is used in combination with corticosteroids (such as cortisone or prednisone), aspirin or phenylbutazone.
Piroxicam can decrease kidney function and cause a sudden severe injury to the kidneys (papillary necrosis).
Blood clotting may be impaired due to the effects of piroxicam on the blood platelets.
As with other NSAIDs, this drug can cause liver injury with elevation of liver enzymes in blood tests.

Medication should never be administered without first consulting your veterinarian.
For an anti-inflammatory effect, piroxicam is dosed at 0.15 mg per pound (0.3 mg/kg) every 24 to 48 hours.
To treat transitional cell carcinoma, piroxicam is dosed at 0.15 mg per pound (0.3 mg/kg) once daily.
For rhinosinusitis in cats, the dose used is 0.15 mg per pound (0.3 mg/kg) once daily. In dogs, 0.15 mg per pound (0.3 mg/kg) every 24 hours has been used for idiopathic lymphoplasmacytic rhinitis.
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse.